What Causes Cancer?
Cancer develops through a combination of an individual’s genetic factors and external carcinogenic (cancer-causing) factors (World Health Organization, 2022). Here are some factors which are associated with greater cancer risk.
Cancer develops through a combination of an individual’s genetic factors and external carcinogenic (cancer-causing) factors (World Health Organization, 2022). Here are some factors which are associated with greater cancer risk.
There is a growing proportion of cancer diagnoses for older age groups. From 1968-1972 to 2016-2020, cancer diagnoses among individuals aged 70 and above increased from 15.7% to 43.2% for males, and 17% to 33.4% for females.
The median age of cancer diagnosis had also increased; from 59.6 to 68.1 years for males; and 57.3 to 63.3 years for females (National Registry of Diseases Office, 2022).
Weight gain and body fatness throughout one’s lifetime mainly depend on excess food consumption and physical inactivity to some extent. Individuals with excess body fat have up to a 9% higher risk of contracting various cancers such as colon, rectum, and breast cancer (Lauby-Secretan et al., 2016).
Eight types of chronic diseases were linked to a statistically greater risk of incident cancer. A combination of cardiovascular disease markers, diabetes, chronic kidney disease markers, pulmonary disease, and gouty arthritis markers was associated with significant cancer risk (Tu et al., 2018).
Lifestyle factors could also contribute to greater cancer risk. Below are some possible factors:
Certain environmental substances could also contribute to greater cancer risk. Below are some possible factors:
References:
1. Behrens, G., Gredner, T., Stock, C., Leitzmann, M. F., Brenner, H., & Mons, U. (2018). Cancers due to excess weight, low physical activity, and unhealthy diet: Estimation of the attributable cancer burden in Germany. Deutsches Ärzteblatt International, 115(35-36), 578-585. https://doi.org/10.3238/arztebl.2018.0578
2. Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K. (2016). Body fatness and cancer — Viewpoint of the IARC working group. New England Journal of Medicine, 375(8), 794-798. https://doi.org/10.1056/NEJMsr1606602
3. National Cancer Institute. (2022a, August 17). The genetics of cancer. https://www.cancer.gov/about-cancer/causes-prevention/genetics
4. National Cancer Institute. (2022b, October 13). Cancer prevention overview (PDQ®)–Patient version. https://www.cancer.gov/about-cancer/causes-prevention/patient-prevention-overview-pdq
5. National Registry of Diseases Office. (2022, December 23). Singapore Cancer Registry Annual Report 2020.
6. Tu, H., Wen, C. P., Tsai, S. P., Chow, W. H., Wen, C., Ye, Y., ... & Wu, X. (2018). Cancer risk associated with chronic diseases and disease markers: Prospective cohort study. The BMJ, 360, Article k134. https://doi.org/10.1136/bmj.k134
7. World Health Organization. (2020, October). Singapore fact sheets. The Global Cancer Observatory. https://gco.iarc.fr/today/data/factsheets/populations/702-singapore-fact-sheets.pdf
8. World Health Organization. (n.d.). Preventing cancer. https://www.who.int/activities/preventing-cancer